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Laboratory of Evolutionary Variability of Influenza Viruses

Laboratory Lead — Mikhail Yu. Eropkin, Dr.Biol.Sci.

Phone: +7 (812) 234–62–63

E–mail: eropkin@influenza.spb.ru






The Laboratory of Evolutional Variability of Influenza was formed in 1967. In 1972, it became a part of RII National and Federal Influenza Centres. During 1967–1990, the laboratory was headed by Prof. T. Luzyanina and S. Galitarov, SciD. Today, it is a modern BSL3-compliant facility engaged in a wide range of biomedical research.

Primary Activities

  • Etiological influenza surveillance in Russia
  • Analysis and comparative studies of viruses circulating in Russia and international specimen with the purpose of detecting viruses with epidemic potential
  • Studies of receptor specificity of influenza viruses to predict shifts and expansions in the range of host species

Results of the research serve as a basis for national recommendations on vaccine composition for epidemic seasons. The laboratory conducts: 

  • Trials of antiviral preparations on cell cultures, chicken embryos and mice.
  • In-vitro trials of safety and toxicity of various nanotechnology-based compounds/materials,
  • Design of polymer modified antiviral preparations and antibiotics(in collaboration with RAS Institute of Macromolecular Compounds)

The staff is actively cooperating with WHO Influenza Collaborating Centres at NIMR, London, UK and CDC, Atlanta, USA, exchanging data, strains, reagents and conducting mutual studies. The lab took part in the ISTC Project 3070, which saw a considerable increase in isolation and exchange of influenza strains in Russia. A vast Collection of Viruses is maintained by the laboratory, with over 15.000 stored samples.


Recent Achievements

Selected Publications

  • «Antigenic and Biological Properties of Influenza Type B Viruses Isolated in Russia in 2006–2010»
    A. V. Ivanova, D. M. Danilenko, T. G. Lobova et al.
    Epidemiology & Vaccinal Prevention. 2011;56(1):4–8 In Russian
  • «Dependence of biological effects of fullerene C60 in vitro from the type of preparations»
    B. Piotrovsky, M. A. Dumpis, E. V. Litasova, M. Yu. Eropkin, E. M. Eropkina, O. I. Kiselev.
    Fullerenes, Nanotubes and Carbon Nanostructures. 2011;19(1):147–153
  • «The 2009 pandemic influenza in Russia. I. Diagnosis and molecular biological characteristics of the virus»
    O. I. Kiselev, A. B. Komissarov, M. A. Stukova et al.
    Vopr Virusol. 2011 Jan-Feb;56(1):17-21 In Russian
  • «Mechanisms and models of toxicity research at the cellular level»
    M. Yu. Eropkin
    Applied Toxicology. 2010;1(2):30–49 In Russian
  • «Complexes of aminoglycoside antibiotics with copolymers of acrylamide with acrylic and methacrylic acids»
    M. V. Solovskii, M. Yu. Eropkin, E. M. Eropkina, M. Yu. Smirnova and I. I. Gavrilova.
    Pharmaceutical Chemistry Journal. 2010;44(6):314–318
  • «Etiological characteristics of the influenza epidemics of 2006-2009 in the Russian Federation (according to the data of the Research Institute of Influenza, North-Western Branch, Russian Academy of Medical Sciences)»
    N.I. Konovalova, M.Iu. Eropkin, T.M. Gudkova, V.A. Grigor'eva, D.M. Danilenko, A.V. Ivanova, T.S. Smirnova, T.G. Lobova, S.M. Shchekanova.
    Vopr Virusol. 2010 Jul-Aug;55(4):9-16 In Russian
  • «Study of the antiviral activity of Russian anti-influenza agents in cell culture and animal models»
    I. A. Leneva, I. T. Fediakina, M. Yu. Eropkin, N. V. Gudova, A. A. Romanovskaia, D. M. Danilenko, S. M. Vinogradova, A. Yu. Lepeshkin, A. M. Shestopalov.
    Vopr Virusol. 2010 May-Jun;55(3):19-27 In Russian
  • «2009 Pandemic Influenza in Russia: antigenic and biological properties and sensitivity to drugs»
    M. Yu. Eropkin, T. M. Gudkova, D. M. Danilenko, N. I. Konovalova, V. A. Grigor'eva, M. Yu. Smirnova, A. V. Ivanova, T. S. Bryazhikova, E. M. Eropkina, S. M. Shchekanova.
    Rus Med J. 2010;18(7):410–415 In Russian
  • «Biological effects in cell cultures of fullerene C60 — dependence on aggregation state. Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes»
    L. Piotrovsky, M. Eropkin, E. Eropkina, M. Dumpis, O. Kiselev.
    Eds. F. Cataldo and T. da Ros, Springer, 2008. P. 139–155
  • «Biochemical Methods in Toxicology and Ecotoxicology. Textbook»
    M. Yu. Eropkin, N. V. Kuleva.
    St.Petersburg, SPb. University Publ. House, 2008, 104 p In Russian
  • «Cytotoxicity and antibacterial activity of polymeric complexes of aminoglycoside antibiotics »
    M. V. Solovskii, M. Yu. Eropkin, E. M. Eropkina, I. I. Gavrilova, E. L. Shultseva
    Vopr. Biol. Med. Farm. Khim. 2008;(2):10–14
  • «About the WHO National Influenza Centre at the Research Institute of Influenza»
    A. A. Sominina, O. I. Kiselev, M. P. Grudinin, M. Yu. Eropkin, V. V. Zarubaev, I. G. Marinich
    Influenza and ILI. Problem Committee Bulletin. 2008;(2): 14–22 In Russian
  • «Molecular characteristic of influenza virus A H5N1 Strains isolated from poultry in Kurgan Region in 2005»
    O. I. Kiselev, V. M. Blinov, M. M. Pisareva, V. A. Ternovoĭ, A. P. Agafonov, D. V. Saraev, M. Yu. Eropkin, T. G. Lobova, V. A. Grigor'eva, M. P. Grudinin.
    Mol Biol (Mosk). 2008 Jan-Feb;42(1):78-87 In Russian
  • «Laboratory Surveillance in Russia at Phase 3 of Influenza Pandemic. Options of the Control of Influenza IV»
    A. Sominina, T. R. Tsareva, E. V. Sorokin, I. V. Amosova, V. Z. Krivitskaya, M. A. Pisareva, M. Y. Eropkin, V. V. Zarubaev, N. V. Tretiakova.
    Toronto, Canada. — 2007. — P.258–260
  • «Recent features of evolution of influenza A (H1N1) viruses in Russia. Options of the Control of Influenza IV»
    M. Yu. Eropkin, N. I. Konovalova, T. M. Grigorieva, T. M. Gudkova, I. B. Yaglovskaya, M. P. Grudinin, M. M. Stukova, M. A. Pisareva.
    Toronto, Canada. — 2007. — P. 408–409
  •  «Synthesis and Properties of Low-Molecular-Weight Copolymers of Acrylamide with 2-Acrylamido-2-methylpropanesulfonic Acid, as Potential Drug Carriers»
    M. V. Solovskii, M. Yu. Eropkin, E. M. Eropkina, A. V. Slita, M. Yu. Smirnova, E. N. Vlasova, E. B. Tarabukina, and A. I. Amirova.  
    Zh. Prikl. Khim. 2007;80(10):1674–1678 In Russian
  • «Antiviral action of some antioxidants/antihypoxants and their combinations with remantadine against human influenza A(H3N2) virus studied in in vitro models»
    M. Yu. Eropkin, T. M. Gudkova, N. I. Konovalova, S. M. Shchekanova, I. B. Laglovskaia, E. M. Eropkina, O. I. Kiselev.
    Eksp Klin Farmakol. 2007 Sep-Oct;70(5):33-7 In Russian
  • «Studying the effect of antioxidants and/or antihypoxants on cell cultures under conditions of cytotoxic action of rimantadine»
    M. Yu. Eropkin, E. M. Eropkina, O. I. Kiselev.
    Eksp Klin Farmakol. 2007 May-Jun;70(3):56-61 In Russian
  • «Molecular Genetic Properties of Avian Influenza and development of new vaccine strains. Avian Influenza: Prevention and Treatment Methods»
    O. I. Kiselev, A. Egorov, M. P. Grudinin, M. Yu. Eropkin, E. G. Deeva, M. M. Pisareva, M. A. Stukova.
    From conference. 2007.63–71
  • «Epizootics of influenza as a manifestation of pandemic (review article in Russian)»
    E. G. Deeva, M. Yu. Eropkin, V. A.Grigorieva, Yu. N. Akhmedgaleeva, A. V. Korotkov, F. N. Zaytsev, O. I. Kiselev.
    Zh. Mikrobiol. Epidemiol. Immunobiol. 2006;(1):81–87 In Russia

Patents

  • «Water–soluble polymeric complexes of Arbidol»
    M. Yu. Eropkin, M. V. Solovskii, M. Yu. Smirnova, E. F. Panarin, O. I. Kiselev, T. S. Bryazhikova, T. M. Gudkova.
    Patent of the Russian Federation №2394618. Issued 20.07.2010
  • «Preparation with the anti-hypoxic and cytoprotective activities for the purpose to diminish the toxicity of rimantadine in the treatment of influenza infection»
    E. M. Eropkina, O. I. Kiselev, M. Yu. Eropkin, I. A. Tverianovich.
    Patent of Russian Federation №2302236. Issued 2007.07.10
  • «Water-soluble polymeric complexes of aminoglycoside antibiotics and low-molecular weight co-polymers of acrylamide and (met)acrylic acid for them»
    M. V. Solovsky, M. Yu. Eropkin, E. M. Eropkina, O. I. Kiselev, E. F. Panarin, I. I. Gavrilova, E. L. Shultseva.
    Patent of Russian Federation №2006105573/04(006029). Issued 22.02.2006