The monograph written by prof. Oleg I. Kiselev contains an in–depth analysis of the research and development of chemotherapy antivirals against influenza A and B in Russia and worldwide.
Prof. Kiselev reviews the last ten years history and current state of antiviral chemotherapy. The monograph introduces a detailed evaluation of therapeutic and prophylactic effect of antiviral drugs, their pharmacological characteristics, mechanism of their virus-specific and molecular and biological activity, immune modulating and antioxidant properties, impact on the reproduction of highly pathogenic virus strains. Close attention is paid to antiviral drug susceptibility among viruses Also, the monograph gives outlook for future trends in antiviral drug design.
The author outlines the structure of viral components, such as hemagglutinin, neuraminidase, NS, NP and M2 proteins, actually or potentially targeted by chemotherapeutic agents. The book discusses strategy for development of the next 4th generation drugs targeting cell signaling systems.
The monograph records achievements and promising programmes of the Research Institute of Influenza in the field of antiviral drug and vaccine production. In addition, information on recommended antiviral therapy schemes, antiviral drugs currently undergoing clinical trials and summary of viruses (influenza A and B viruses, adenoviruses, RS-viruses, parainfluenza viruses etc.) causing respiratory infections is provided.
The monograph is aimed at virologists, infectologists, pharmacologists, health practitioners and relevant pharmaceutical industry professionals.
