Laboratory of Intercellular Signaling and Transport

The Laboratory of Intracellular Signaling and Transport was founded in 2016.

Main activities

• Research on the intracellular transport of viral proteins in infected cells, including cytoskeleton dynamics and signaling mechanisms involved in the replication cycle of the influenza virus
• Study of various therapeutic ligands in terms of routes of delivery to cellular tagets and their effects on intracellular dynamics
• Creation and study of nanoparticles for the delivery of gene constructs, peptide drugs, and small therapeutic molecules, including particles for bioimaging and their practical application in vitro to study intracellular processes
•  “Cellular miRNAs: new molecular targets for therapy of severe viral infections” (Russian Science Fund grant 15-15-00170)
•  “Preclinical studies of an antiviral, peptide-based drug that suppresses the replication of human influenza A (H1N1) viruses” (state contract 14.N08.11.0080, federal initiative “Development of the Russian pharmaceutical and medical sector until 2020 and beyond”)
•  "Study of the physicochemical and immunogenic properties of virus-like particles based on the core antigen of the hepatitis B virus (HBc) and the ectodomain of the M2 protein of influenza A virus" (state project, 2016)
• The laboratory conducts regular training, both theoretical and practical, in methods including electron microscopy and laser scanning confocal microscopy. In partnership with the North-Western State Medical University named after I.I. Mechnikov (Russian Ministry of Health), the laboratory participates in virology continuing education programs.
• The laboratory actively cooperates with St. Petersburg State University, St. Petersburg State Chemical Pharmaceutical Academy, and Peter the Great St. Petersburg Polytechnic University. Students and graduate students of these higher institutions perform qualification work at the SRII on laboratory research topics.

Epidemic Situation