National Weekly Bulletin

Year: Week:


Week 21.12.2015-27.12.2015

Influenza and ARI morbidity data

Epidemiological data show decrease of influenza and other ARI activity in Russia in comparison with previous week. The nationwide ILI & ARI morbidity level (59.7 per 10 000 of population) was lower than the national baseline for season 2015-2016 (69.5) by 14.1%.

ILI and ARI epidemic thresholds were not exceeded in all of 59 cities collaborating with two WHO NICs in Russia.

Exceeding of morbidity epidemic thresholds for overall population
 
- No data - less 20% - 20 - 49% - 50% and more


Cumulative number of diagnosed influenza cases

Cumulative results of influenza laboratory diagnosis by different tests were submitted by 50 RBLs and two WHO NICs. According to these data as a result of 2054 patients investigation the overall proportion of respiratory samples positive for influenza was estimated as 6.9%, including 5.7% for influenza A(H1N1)pdm09 virus, 0.7% for influenza A(H3N2) virus, 0.4% for influenza A and 0.1% for influenza B virus. 

Results of influenza diagnosis
 
- No data
- No detection
- H1pdm09
- H1pdm09+H1
- H1pdm09+B
- H1pdm09+B+H1
- H1pdm09+H3
- H1pdm09+H3+H1
- H1pdm09+H3+B
- H1pdm09+H3+H1+B
- H1
- B
- B+H1
- H3
- H3+H1
- H3+B
- H3+H1+B


Influenza Virus Isolation



  - B - A(H1N1) - A(H3N2) - A(H1N1)pdm09  


Influenza Virus Antigen Detection by Immunofluorescence Assay (IFA)



  - B - A(H1N1) + A(H1N1)pdm09 - A(H3N2)  
  - PIV - AD - RS  


Influenza Virus RNA Detection by RT-PCR



  - B - A(H1N1) - A(H3N2) - A(H1N1)pdm09  
  - PIV - AD - RS    


Table 1. Influenza Virus Isolation
Base lab. Number of
investigated
patients
Number of viruses isolated
H1 H3 B H1pdm09 Untyped
virus
Total
BL of RII68000000
(%) 0,00,00,00,00,00,0
BL of IV4301021022
(%) 0,02,30,048,80,051,2
TOTAL11101021022
(%) 0,00,90,018,90,019,8

Table 2. Influenza Virus Antigen Detection by Immunofluorescence Assay (IFA)
Base lab. Number of
investigated
patients
Influenza Parainfluenza AD RS Total
H1+H1pdm09 H3 B I II III
BL of RII5862022521532127151
(%) 0,30,00,34,33,69,03,64,625,8
BL of IV9620055146436
(%) 2,10,00,05,25,214,66,34,237,5
TOTAL6824023026672731187
(%) 0,60,00,34,43,89,84,04,527,4

Table 3. Influenza Virus RNA Detection by RT-PCR
Base lab. Number of
investigated
patients
Influenza PIV AD RS
A
(not subtyped)
H1 H3 H5 B H1pdm09
BL of RII13220 / 13220 / 60210 / 6600 / 4920 / 132254 / 88773 / 110147 / 1101180 / 1101
(%) 0,00,01,50,00,06,16,64,316,3
BL of IV3138 / 3130 / 95 / 2080 / 90 / 31361 / 2046 / 964 / 10113 / 101
(%) 2,60,02,40,00,029,96,34,012,9
TOTAL16358 / 16350 / 61115 / 8680 / 5010 / 1635115 / 109179 / 119751 / 1202193 / 1202
(%) 0,50,01,70,00,010,56,64,216,1

Table 4. Cumulative number of diagnosed influenza cases
Base lab. Number of
investigated
patients
Number of diagnosed influenza cases
H1 H1+H1pdm09
(IFA)
H3 A
(not subtyped)
B H1pdm09 Total
BL of RII17230210025567
(%) 0,00,10,60,00,13,23,9
BL of IV331025806275
(%) 0,00,61,52,40,018,722,7
TOTAL2054041582117142
(%) 0,00,20,70,40,105,76,9

Conclusion

Influenza and ARI morbidity data.  Decreased influenza and other ARI activity was registered during the week 52.2015 in traditional surveillance system in Russia. The nationwide ILI & ARI morbidity level (59.7 per 10 000 of population) was lower than the national baseline by 14.1%.

Etiology of ILI & ARI morbidity. The overall proportion of respiratory samples tested positive for influenza  was estimated as 6.9%. Percent of positive ARI cases of non-influenza etiology (PIV, adeno- and RSV) was estimated as 26.5% of investigated patients by IFA and 26.9% by PCR. 

Antigenic characterization. Since start of 2015-2016 season 24 influenza virus was characterizated antigenically including 23 A(H1N1)pdm09 viruses and 1 influenza A(H3N2) virus. 23 (95.8%) influenza A(H1N1)pdm09 viruses were antigenically similar vaccine strain A/California/07/09.  One influenza A(H3N2) virus was antigenically characterizated as A/Switzerland/9715293/2013-like.

In sentinel surveillance system clinical samples from 51 SARI and ILI/ARI patients were investigated by rRT-PCR. 2 influenza A(H1N1)pdm09 SARI cases and 1 influenza ILI/ARI case were detected.