Research activities at the federal Smorodintsev Research Institute of Influenza (div. Russian Ministry of Health) focus on finding solutions to fundamental and applied problems in the fields of virology, epidemiology, and infectious disease. The Institute aims to preserve and strengthen human health, to develop health care, and to advance medical science.
Main Areas of Scientific Research:
Improvement of epidemiological and etiological monitoring of influenza and other acute respiratory infections in Russia. Expansion of collaboration with the World Health Organization.
Molecular genetic and phylogenetic analysis of influenza viruses circulating in Russia. Prediction of variability trends in influenza and other viral agents.
Identification and classification of genetic determinants behind the pathogenicity of existing and emerging viruses. Development of methods for the proper placement or clarification of new viruses taxonomically.
Study of the molecular mechanisms underlying the pathogenesis of viral infections and the morphology of viruses.
Creation of a new generation of reagents based on nanotechnologies. Development of viral infection diagnostic reagents, including reagents which characterize the status of cytokines and other immunity factors. Incorporation of such reagents into healthcare practice. Creation of oligonucleotide and protein microchips, test systems, and rapid diagnostic preparations.
Development of approaches to the creation of new generation influenza vaccines. Use of nanotechnology in order to obtain effective and modern means of protecting the population from influenza and other dangerous infections.
Search for new antiviral drugs of both natural and synthetic origin. Directional synthesis of compounds and comprehensive study of inhibitory (antiviral) effects.
Experimental and clinical study of the safety, immunogenic properties, and efficacy of drugs for the prevention of viral infections.
Study of severe and complicated forms of influenza and other acute respiratory infections (in both children and adults) in terms of pathogenesis and improvement of treatment regimens.
Development of biological repository systems. Expansion and curation of collections: influenza viruses; acute respiratory infection pathogens; cell cultures; and hybridomas for monoclonal antibody production. Creation of electronic and printed catalogs.